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Приєднався 16 лип 2006
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Terms and conditions: wb.md/2vpzLGV
Terms and conditions: wb.md/2vpzLGV
The Race to Get Drugs to Market
Elcin Barker Ergun, CEO of the Menarini Group, talks about a renewed interest in drug development to address unmet needs while shaping policy.
www.staging.medscape.com/s/viewarticle/race-get-drugs-market-2024a1000bym?src=soc_yt
--TRANSCRIPT--
JOHN WHYTE: Welcome, everyone. I'm Dr. John Whyte. I'm the chief medical officer at WebMD. I'm here at the American Society of Clinical Oncology meeting, talking to my good friend, Elcin Barker Ergun, the president and CEO of Menarini Group. Elcin, it's great to see you again.
ELCIN BARKER ERGUN: Happy to be here and catch up.
JOHN WHYTE: I last saw you a year ago in Florence, where one of the best slides you've had that everyone has picked up is, you talked about there's a renaissance. We were in Florence, but still a renaissance in drug development. Do you still feel that way?
ELCIN BARKER ERGUN: I do. I do, actually. Yeah. So we have more and more interesting things coming. Last time we spoke about diagnostics a bit. We talked about biomarker drugs. I think maybe we talked about AI a little bit. And then of course there are ADCs. Many companies are now looking at ADC platforms. There's cell and gene therapy. So there's a lot of excitement and a lot of development. We talked about very difficult-to-treat mutations like KRAS, et cetera, and drugs coming.
And when you look at here, there's more data that we are seeing. I think it's all also about how they will come together. Oncology, when we talk about oncology, oncology is all about sequencing. So I always think it's very good that we will have drugs like ADCs, but at the same time, you will always have room for small molecules because, again, based on the characteristics of the patient and more and more targeted ways we are going, you have to really use them in the right sequence.
If you think about some metastatic diseases, breast, et cetera, if you do that sequencing right, you're going to give patients, even in metastatic disease, say, up to 10 years, rather than maybe 3 years. And you know what I mean, maybe then not so many things afterwards.
JOHN WHYTE: Now, something that's moving very fast is the topic of AI. And when you and I chatted a year ago, you were very measured about it. There are some folks who think it's going to change the whole drug development process and the way you treat patients. You were more like, "Hold on, John. It's a wait-and-see approach." How has your opinion changed, if at all?
ELCIN BARKER ERGUN: I'm still there. But if you look at what has happened afterwards, so it's always like a rush. It's a gold rush. I never see it like that because I still think that in discovery, you get a lot of efficiency with this approach, and which I still see is the No. 1 place where generative AI is going to help us.
But then you need chemical platform in order to validate that. In order to really make sure you have a really great lead asset, you optimize that and then you validate it through the traditional methodology. And the last time I remember, we spoke about regulation. And actually very quickly after that, both US and Europe came up with a regulation. Regulation is needed, definitely needed, and they're putting a lot of emphasis on screening.
JOHN WHYTE: Something you've been a leader in, and enough CEOs aren't talking about this, is the issue of antimicrobial resistance. And you and I chatted, when we were in Florence, you and I chatted about it a few months ago by phone. What do we need to be doing because here we're talking obviously a lot about cancer care, which is important, but at the same time, we've learned certainly over the last few years the issue of AMR? And do we have good stewardship? Do we have good drug development and investment?
ELCIN BARKER ERGUN: I'm really glad you brought that point again, because I feel we haven't made a leapfrog there. So it's still a very little, little improvement in the sense that some--
JOHN WHYTE: But why? Why given how many people are impacted?
ELCIN BARKER ERGUN: You're right. I think the issue is fit. Correctly, in the beginning, it was more about how do we make sure there's a pipeline coming. The fact is, with some of these IFPMA-supported fund, AMR Action Fund, et cetera, there are some drugs that are coming now out of the pipeline. The problem is there isn't enough incentive, pricing access incentive, to get them to the market. And that's a big problem.
Now, essentially the problem is accumulating and accumulating because there isn't a real-- currently the drugs are not reaching the market. And that is a huge problem still. And it's a big threat for everyone because it was 1 million, then 2 million, 3 million. And at some point, the death toll is going to be very, very high.
Transcript in its entirety can be found by clicking here: www.staging.medscape.com/s/viewarticle/race-get-drugs-market-2024a1000bym?src=soc_yt
www.staging.medscape.com/s/viewarticle/race-get-drugs-market-2024a1000bym?src=soc_yt
--TRANSCRIPT--
JOHN WHYTE: Welcome, everyone. I'm Dr. John Whyte. I'm the chief medical officer at WebMD. I'm here at the American Society of Clinical Oncology meeting, talking to my good friend, Elcin Barker Ergun, the president and CEO of Menarini Group. Elcin, it's great to see you again.
ELCIN BARKER ERGUN: Happy to be here and catch up.
JOHN WHYTE: I last saw you a year ago in Florence, where one of the best slides you've had that everyone has picked up is, you talked about there's a renaissance. We were in Florence, but still a renaissance in drug development. Do you still feel that way?
ELCIN BARKER ERGUN: I do. I do, actually. Yeah. So we have more and more interesting things coming. Last time we spoke about diagnostics a bit. We talked about biomarker drugs. I think maybe we talked about AI a little bit. And then of course there are ADCs. Many companies are now looking at ADC platforms. There's cell and gene therapy. So there's a lot of excitement and a lot of development. We talked about very difficult-to-treat mutations like KRAS, et cetera, and drugs coming.
And when you look at here, there's more data that we are seeing. I think it's all also about how they will come together. Oncology, when we talk about oncology, oncology is all about sequencing. So I always think it's very good that we will have drugs like ADCs, but at the same time, you will always have room for small molecules because, again, based on the characteristics of the patient and more and more targeted ways we are going, you have to really use them in the right sequence.
If you think about some metastatic diseases, breast, et cetera, if you do that sequencing right, you're going to give patients, even in metastatic disease, say, up to 10 years, rather than maybe 3 years. And you know what I mean, maybe then not so many things afterwards.
JOHN WHYTE: Now, something that's moving very fast is the topic of AI. And when you and I chatted a year ago, you were very measured about it. There are some folks who think it's going to change the whole drug development process and the way you treat patients. You were more like, "Hold on, John. It's a wait-and-see approach." How has your opinion changed, if at all?
ELCIN BARKER ERGUN: I'm still there. But if you look at what has happened afterwards, so it's always like a rush. It's a gold rush. I never see it like that because I still think that in discovery, you get a lot of efficiency with this approach, and which I still see is the No. 1 place where generative AI is going to help us.
But then you need chemical platform in order to validate that. In order to really make sure you have a really great lead asset, you optimize that and then you validate it through the traditional methodology. And the last time I remember, we spoke about regulation. And actually very quickly after that, both US and Europe came up with a regulation. Regulation is needed, definitely needed, and they're putting a lot of emphasis on screening.
JOHN WHYTE: Something you've been a leader in, and enough CEOs aren't talking about this, is the issue of antimicrobial resistance. And you and I chatted, when we were in Florence, you and I chatted about it a few months ago by phone. What do we need to be doing because here we're talking obviously a lot about cancer care, which is important, but at the same time, we've learned certainly over the last few years the issue of AMR? And do we have good stewardship? Do we have good drug development and investment?
ELCIN BARKER ERGUN: I'm really glad you brought that point again, because I feel we haven't made a leapfrog there. So it's still a very little, little improvement in the sense that some--
JOHN WHYTE: But why? Why given how many people are impacted?
ELCIN BARKER ERGUN: You're right. I think the issue is fit. Correctly, in the beginning, it was more about how do we make sure there's a pipeline coming. The fact is, with some of these IFPMA-supported fund, AMR Action Fund, et cetera, there are some drugs that are coming now out of the pipeline. The problem is there isn't enough incentive, pricing access incentive, to get them to the market. And that's a big problem.
Now, essentially the problem is accumulating and accumulating because there isn't a real-- currently the drugs are not reaching the market. And that is a huge problem still. And it's a big threat for everyone because it was 1 million, then 2 million, 3 million. And at some point, the death toll is going to be very, very high.
Transcript in its entirety can be found by clicking here: www.staging.medscape.com/s/viewarticle/race-get-drugs-market-2024a1000bym?src=soc_yt
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They don't have a "good" experience in the hospital. Why is that?
Him: "Using the ball makes it more fun" Me: "Please kill me"
Too fast to follow
Your favorite muscle you say?
Aren't the voices supposed to stop when i pause the video?😶
Can anyone please tell how to remove nits?
So real I dill with it everyday
Singers
If u want to get rid of migrane problem.. Do - 1- Pranayam 2- Shirsh-asan
In the Godzilla of 1985 there where radiated sea lice it was actually terrifying
🤮 🤮 🤮 🤮
🤢 🤢 🤢 🤢
🤮 🤮 🤮 🤮
🤢 🤢 🤢 🤢
I have been depressed for a long time, but after taking mushrooms few months ago, l feel much happier and highly motivated and my ADHD gone , lost a ton of anxiousness and had a few epiphanies about how I should live my life. I decided to buy an ounce for backup, but haven’t yet felt the need to take any more since then.
same here. Shrooms saved me and I will forever be grateful
Why are you in the ocean, without a life vest if you can’t swim 💀💀
Obviously not an English professional. You're looking for taut.
I encourage anyone with cancer or any disease to look into mushrooms like turkey tails, red reishie, chaga, etc. There's a lot pharmaceutical industry hides from us, lots of money for one.
It's wonderful to see you take action in despite of your difficulties. My symptoms are slightly different but there are a lot of similarities in the mental struggle. Keep pushing. You got this. 👍
Super de faire tout une gamme de produits pour aider les gens ! Je veux acheter aussi quelque chose 😊
Merci beaucoup !🌸
Guys I think I just had one for the second time. Came on lasted a minute, pain was so intense and my goodness that hurt. Lasted maybe a minute. Nausea yes…. Happened a few hours ago and I’m starting to feel a little better yet I’m still feeling a bit wierd in my head! On one side opposite side of where my headache was now that I think about it. I mean my whole head hurt but it seemed to be concentrated on one side and mostly my temple and eye and back of the head n neck area.
Thanks
The cause is the cure....were all different one size doesn't fit all
I'm glad to hear u talk on this. I have a relative who was diagnosed with ADD. Thank GOD his mother didn't give up on his diagnosis. He later was diagnosed with Psychosis. As a child he heard voices & docs kept saying ADD. Ritalin stopped working, but the voices didn't go away. He learned with GOD & his docs to deal with the voices. With GOD he learned right from wrong & choose right! WWJD!!!
i have lice right now and my hair is to thick to comb it out
I have been suffering from Bad Breath for the past 10 vear. I was cure completel after using the herbal medicine I got from Dr ohanon,,💐
I just got mine,my daughter says I look like I have an elephants nose 😂 1st night with it the straps were hurting my neck and I was constantly taking it off to blow my nose. I have a deviated septum that dries my sinuses, guess I should bump up the humidifier. Breathing only through my nose through the mask for some reason also caused slight chest pain, they typical kind when you put extra effort in to pushing out air.
Look.. they are trying to scare people into getting more vaccines.. it's a damn shame..
Thnx for the video. I read that cannabis may cause psychosis in autism, and change a part of the brain related to schizophrenia in offspring.
Keto is bad for business.. drugs free and down for 10 years.. zero cac scan score
This was extremely helpful very we'll explained and helped me understand. Thanks ever so much
We are alone
Men can in a sense have multiple orgasms mainly via stimulating the prostate because the refractory period for a prostate orgasm is shorter.
Thats wrong you can sneeze with your eyes open, Ive done it a few times and felt very weird.
Wow Your analogy speaking about The Fog wow!! I get it!! 🤗
Patanjali Wellness Haridwar.
Wow excellent video thank u so so much for sharing very useful information 👌🏽👌🏽👌🏽🥰🥰🥰🥰♥️♥️♥️♥️💐💐💐💐🥀🥀🥀🥀
❤
It's pain is similar to a broken limb. Simply excruciating.. How to avoid it. 1. Avoid meat. 2. Avoid Sugary drinks. 3. Avoid excess protein.
Ok Mrs farty/party 🎉🥳😎
I jumped in a 7 foot once, I wasn't even 5 feet tall at the time. I didn't know how to swim. By God's grace, I managed to remain calm and sink to the bottom. I simply bobbed up and down until I made it to the shallow end. I don't think it would have worked in deeper water.
Anybody here in 2024
Yes
I Have Aspergers And Im Extremely Bad At Being Social Aswell As Being Bad At Basic Algebra
I've done rmt/physi/chiro with little to no results. One session of acupuncture and conditions I've had for years and felt hopeless would ever be resolved were gone in a single session. I just want to know how it actually works and why it is apparently able to have profound effects on my body.
Why is this person 12
They save you from living on earth any longer or just make it living h3ll on earth
So theyre basically glitches
A Legacy of Love. Rest in Peace Will.
Bro I had a hard wierd small pimple like blister in my chest now for 2 months and I just squeezed it a little and it burst and yellow substance came out of it . I didn't expected this to happen lol